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Research Corner: Timing of Medications Can Help Improve Blood Pressure

A recent article indicates that taking blood pressure medications at a different time of day may help improve blood pressure in people with type 2 diabetes.

Tip to take away:  For people with diabetes and hypertension, taking blood pressure medications in the evening may improve your blood pressure control. Discuss your current medication routine with your healthcare provider to find out how you can get the best results.

Study summary:  This study included 448 participants with both type 2 diabetes and hypertension.  The researchers randomly divided the patients into two groups.  One group took all of their hypertensive medications in the morning upon waking.   The other group took 1 or more of their medications at night (bedtime).  These participants had follow-up through the study for an average of 5-1/2 years.  The subjects had their blood pressure measured over a 48-hour period at baseline and were required to have annual and sometimes quarterly monitoring of their blood pressure throughout the study.  The results of both groups were analyzed and compared.

The group that took their hypertensive medications at bedtime showed significantly lower blood pressure than the group that took their blood pressure medications in the morning. The “bedtime” group also had an added benefit of reducing their risk of heart disease. This effect has also been seen in other studies where sleep time blood pressure has declined in patients with diabetes as well as patients who don’t have diabetes.

Reference:  Hermida RC, Mojon A, Ayala DE, Fernandez JR.  Influence of Time of Day of Blood Pressure-Lowering Treatment on Cardiovascular Risk in Hypertensive Patients with Type 2 Diabetes  (Diabetes Care, 34:1270-1276, 2011)

 Abstract available at:

For more information about hypertension and blood pressure control, visit these resources:

Fit4D’s Research Corner is a feature section where we summarize the latest research studies in diabetes management and provide practical tips based on the findings. Check back regularly for more Research Corner updates!

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3 Awesome Comments So Far

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    September 27, 2011 at 8:10 am #

    Thx for this great information that you are sharing with us!!!

  2. Stephen in Birmingham
    April 20, 2012 at 1:18 am #

    Hey this is a really interesting post. I have been been looking into current clinical research on hypertension. Hypertension and type 2 diabetes are rising issues in America.

  3. Marry White
    September 30, 2012 at 8:03 am #

    I was looking for this specific the other day. i won’t commonly post throughout forums but i want to to say thank you!

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